The pharmacogenetics of type 2 diabetes: a systematic review.

ABSTRACT:

Objective

We performed a systematic review to identify which genetic variants predict response to diabetes medications.

Research design and methods

We performed a search of electronic databases (PubMed, EMBASE, and Cochrane Database) and a manual search to identify original, longitudinal studies of the effect of diabetes medications on incident diabetes, HbA1c, fasting glucose, and postprandial glucose in prediabetes or type 2 diabetes by genetic variation. Two investigators reviewed titles, abstracts, and articles independently. Two investigators abstracted data sequentially and evaluated study quality independently. Quality evaluations were based on the Strengthening the Reporting of Genetic Association Studies guidelines and Human Genome Epidemiology Network guidance.

SUBMITTER: Maruthur NM 

PROVIDER: S-EPMC3931386 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature