Effects of severing the corpus callosum on electrical and BOLD functional connectivity and spontaneous dynamic activity in the rat brain.

ABSTRACT: Functional networks, defined by synchronous spontaneous blood oxygenation level-dependent (BOLD) oscillations between spatially distinct brain regions, appear to be essential to brain function and have been implicated in disease states, cognitive capacity, and sensing and motor processes. While the topographical extent and behavioral function of these networks has been extensively investigated, the neural functions that create and maintain these synchronizations remain mysterious. In this work callosotomized rodents are examined, providing a unique platform for evaluating the influence of structural connectivity via the corpus callosum on bilateral resting state functional connectivity. Two experimental groups were assessed, a full callosotomy group, in which the corpus callosum was comple

SUBMITTER: Magnuson ME 

PROVIDER: S-EPMC3931437 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature