Enhanced detection of metastatic prostate cancer cells in human plasma with lipid bodies staining.

ABSTRACT:

Background

Reprogramming of energy metabolism of malignant cancer cells confers competitive advantage in growth environments with limited resources. However, not every process of cancer development is associated with competition for resources. During hematogenous transport, cancer cells are exposed to high levels of oxygen and nutrients. Does energy metabolism of cancer cells change as a function of exposure to the bloodstream? Could such changes be exploited to improve the detection of circulating tumor cells (CTC)? These questions have clinical significance, but have not yet been sufficiently examined.

Methods

The energy metabolism was examined as a function of incubation in nutrient-rich plasma in prostate metastatic cancer cells LNCaP and non-transformed prostate epithel

SUBMITTER: Mitra R 

PROVIDER: S-EPMC3931481 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature