Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis.

ABSTRACT: The large number of RNA-binding proteins and translation factors encoded in the Drosophila and other metazoan genomes predicts widespread use of post-transcriptional regulation in cellular and developmental processes. Previous studies identified roles for several RNA-binding proteins in dendrite branching morphogenesis of Drosophila larval sensory neurons. To determine the larger contribution of post-transcriptional gene regulation to neuronal morphogenesis, we conducted an RNA interference screen to identify additional Drosophila proteins annotated as either RNA-binding proteins or translation factors that function in producing the complex dendritic trees of larval class IV dendritic arborization neurons. We identified 88 genes encoding such proteins whose knockdown resulted in aberrant d

SUBMITTER: Olesnicky EC 

PROVIDER: S-EPMC3931563 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature