Prognostic value of perineural invasion in gastric cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

The prognostic role of perineural invasion in gastric cancer is controversial. Here, we present a systemic review and meta-analysis of the association between perineural invasion and survival in resectable gastric cancer patients.

Methods

A comprehensive literature search for relevant reports published up to April 2013 was performed using PubMed, Embase, Web of Science and Wanfang Data. Studies that investigated the role of perineural invasion with a sample size greater than 100 were included and analyzed.

Results

A total of 30,590 gastric cancer patients who had undergone curative gastrectomy from twenty-four studies were included. The median rate of perineural invasion positive was 40.9% (6.8%-75.6%). Fourteen studies investigated overall survival unadjus

SUBMITTER: Deng J 

PROVIDER: S-EPMC3931634 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature