A compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytes.

ABSTRACT: The β1-adrenergic signaling system plays an important role in the functioning of cardiac cells. Experimental data shows that the activation of this system produces inotropy, lusitropy, and chronotropy in the heart, such as increased magnitude and relaxation rates of [Ca(2+)]i transients and contraction force, and increased heart rhythm. However, excessive stimulation of β1-adrenergic receptors leads to heart dysfunction and heart failure. In this paper, a comprehensive, experimentally based mathematical model of the β1-adrenergic signaling system for mouse ventricular myocytes is developed, which includes major subcellular functional compartments (caveolae, extracaveolae, and cytosol). The model describes biochemical reactions that occur during stimulation of β1-adrenoceptors, changes in i

SUBMITTER: Bondarenko VE 

PROVIDER: S-EPMC3931689 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature