The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.

ABSTRACT: Vascularization of the placenta is a critical developmental process that ensures fetal viability. Although the vascular health of the placenta affects both maternal and fetal well being, relatively little is known about the early stages of placental vascular development. The ubiquitin ligase Ankyrin repeat, SOCS box-containing 4 (ASB4) promotes embryonic stem cell differentiation to vascular lineages and is highly expressed early in placental development. The transcriptional regulator Inhibitor of DNA binding 2 (ID2) negatively regulates vascular differentiation during development and is a target of many ubiquitin ligases. Due to their overlapping spatiotemporal expression pattern in the placenta and contrasting effects on vascular differentiation, we investigated whether ASB4 regulates ID

SUBMITTER: Townley-Tilson WH 

PROVIDER: S-EPMC3931756 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature