Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency.

ABSTRACT:

Background

Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is highly prioritized. To date, proposed in vitro assays are mainly based on single biomarkers, which so far have not been able to classify and stratify chemicals into subgroups, related to risk or potency.

Methods

Recently, we presented the Genomic Allergen Rapid Detection (GARD) assay for assessment of chemical sensitizers. In this paper, we show how the genome wide readout of GARD can be expanded and used to identify differentially regulated pathways relating to individual chemical sensitizers. In this study, we investigated the mechanisms of action of a range of skin s

SUBMITTER: Albrekt AS 

PROVIDER: S-EPMC3932014 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature