Peptide sharing between influenza A H1N1 hemagglutinin and human axon guidance proteins.

ABSTRACT: Epidemiologic data suggest that maternal microbial infections may cause fetal neurodevelopmental disorders, potentially increasing susceptibility to heavy psychopathologies such as schizophrenia, schizophreniform disorder, autism, pervasive developmental disorders, bipolar disorders, psychosis, epilepsy, language and speech disorders, and cognitive impairment in adult offspring. However, the molecular pathomechanisms underlying such a relationship are not clear. Here we analyze the potential role of the maternal immune response to viral infection in determining fetal brain injuries that increase the risk of neurological disorders in the adult. We use influenza infection as a disease model and human axon guidance pathway, a key process in the formation of neural network during midgestation,

SUBMITTER: Lucchese G 

PROVIDER: S-EPMC3932078 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature