New insights into molecular mechanisms of diabetic kidney disease.

ABSTRACT: Diabetic kidney disease remains a major microvascular complication of diabetes and the most common cause of chronic kidney failure requiring dialysis in the United States. Medical advances over the past century have substantially improved the management of diabetes mellitus and thereby have increased patient survival. However, current standards of care reduce but do not eliminate the risk of diabetic kidney disease, and further studies are warranted to define new strategies for reducing the risk of diabetic kidney disease. In this review, we highlight some of the novel and established molecular mechanisms that contribute to the development of the disease and its outcomes. In particular, we discuss recent advances in our understanding of the molecular mechanisms implicated in the pathogenes

SUBMITTER: Badal SS 

PROVIDER: S-EPMC3932114 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature