Detecting association of rare variants by testing an optimally weighted combination of variants for quantitative traits in general families.

ABSTRACT: Although next-generation sequencing technology allows sequencing the whole genome of large groups of individuals, the development of powerful statistical methods for rare variant association studies is still underway. Even though many statistical methods have been developed for mapping rare variants, most of these methods are for unrelated individuals only, whereas family data have been shown to improve power to detect rare variants. The majority of the existing methods for unrelated individuals is essentially testing the effect of a weighted combination of variants with different weighting schemes. The performance of these methods depends on the weights being used. Recently, researchers proposed a test for Testing the effect of an Optimally Weighted combination of variants (TOW) for unrel

SUBMITTER: Fang S 

PROVIDER: S-EPMC3932153 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature