SOCS1 prevents graft arteriosclerosis by preserving endothelial cell function.

ABSTRACT:

Objectives

The aim of this study was to determine the role of suppressor of cytokine signaling 1 (SOCS1) in graft arteriosclerosis (GA).

Background

GA, the major cause of late cardiac allograft failure, is initiated by immune-mediated endothelial activation resulting in vascular inflammation and consequent neointima formation. SOCS1, a negative regulator of cytokine signaling, is highly expressed in endothelial cells (ECs) and may prevent endothelial inflammatory responses and phenotypic activation.

Methods

Clinical specimens of coronary arteries with GA, with atherosclerosis, or without disease were collected for histological analysis. SOCS1 knockout or vascular endothelial SOCS1 (VESOCS1) transgenic mice were used in an aorta transplant model of GA. Mouse aortic ECs

SUBMITTER: Qin L 

PROVIDER: S-EPMC3932325 | biostudies-literature | 2014 Jan 7-14

REPOSITORIES: biostudies-literature