Survivin is a viable target for the treatment of malignant peripheral nerve sheath tumors.

ABSTRACT:

Purpose

To examine the role of survivin as a therapeutic target in preclinical models of human malignant peripheral nerve sheath tumors (MPNST) EXPERIMENTAL DESIGN: Survivin protein expression levels and subcellular localization were examined immunohistochemically in an MPNST tissue microarray. Human MPNST cells were studied in vitro and in vivo; real-time PCR, Western blotting, and immunocytochemical analyses were used to evaluate survivin expression and localization activation. Cell culture assays were used to evaluate the impact of anti-survivin-specific siRNA inhibition on cell growth and cell-cycle progression and survival. The effect of the small-molecule survivin inhibitor YM155 on local and metastatic MPNST growth was examined in vivo.

Results

Survivin was found to b

SUBMITTER: Ghadimi MP 

PROVIDER: S-EPMC3932367 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature