Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P.

ABSTRACT:

Background

To maintain a protective barrier, epithelia extrude cells destined to die by contracting a band of actin and myosin. Although extrusion can remove cells triggered to die by apoptotic stimuli, to maintain constant cell numbers, epithelia extrude live cells, which later die by anoikis. Because transformed cells may override anoikis and survive after extrusion, the direction of extrusion has important consequences for the extruded cell's fate. As most cells extrude apically, they are typically eliminated through the lumen; however, cells with upregulated survival signals that extrude basally could potentially invade the underlying tissue and migrate to other sites in the body.

Results

We found that oncogenic K-Ras cells predominantly extrude basally, rather than apic

SUBMITTER: Slattum G 

PROVIDER: S-EPMC3932369 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature