Symbiote transmission and maintenance of extra-genomic associations.

ABSTRACT: Symbiotes can be transmitted from parents to offspring or horizontally from unrelated hosts or the environment. A key question is whether symbiote transmission is similar enough to Mendelian gene transmission to generate and maintain coevolutionary associations between host and symbiote genes. Recent papers come to opposite conclusions, with some suggesting that any horizontal transmission eliminates genetic association. These studies are hard to compare owing to arbitrary differences in modeling approach, parameter values, and assumptions about selection. I show that associations between host and symbiote genes (extra-genomic associations) can be described by the same dynamic model as conventional linkage disequilibria between genes in the same genome. Thus, covariance between host and sy

SUBMITTER: Fitzpatrick BM 

PROVIDER: S-EPMC3932413 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature