Mining clinical text for signals of adverse drug-drug interactions.

ABSTRACT:

Background and objective

Electronic health records (EHRs) are increasingly being used to complement the FDA Adverse Event Reporting System (FAERS) and to enable active pharmacovigilance. Over 30% of all adverse drug reactions are caused by drug-drug interactions (DDIs) and result in significant morbidity every year, making their early identification vital. We present an approach for identifying DDI signals directly from the textual portion of EHRs.

Methods

We recognize mentions of drug and event concepts from over 50 million clinical notes from two sites to create a timeline of concept mentions for each patient. We then use adjusted disproportionality ratios to identify significant drug-drug-event associations among 1165 drugs and 14 adverse events. To validate our results,

SUBMITTER: Iyer SV 

PROVIDER: S-EPMC3932451 | biostudies-literature | 2014 Mar-Apr

REPOSITORIES: biostudies-literature