Association of common variants of CYP4A11 and CYP4F2 with stroke in the Han Chinese population.

ABSTRACT:

Objective

20-Hydroxyeicosatetraenoic acid has been shown to play an important role in cerebral vascular function. We hypothesized that polymorphisms in genes encoding 20-Hydroxyeicosatetraenoic acid synthesizing enzymes might confer susceptibility to stroke.

Methods and results

To test the hypothesis, haplotype tagging single nucleotide polymorphisms and potential functional polymorphisms of CYP4A11 and CYP4F2 genes were genotyped in 558 ischemic stroke patients, 221 hemorrhagic stroke patients and 557 controls. The association analyses were performed at both single nucleotide polymorphism and haplotype levels. We further verified our findings in an independent cohort of 551 ischemic stroke cases and 48 hemorrhagic stroke cases and 694 unaffected controls. We identified CYP4

SUBMITTER: Ding H 

PROVIDER: S-EPMC3932492 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature