Genetic variation in multiple biologic pathways, flavonoid intake, and breast cancer.

ABSTRACT:

Purpose

We previously reported an inverse association between flavonoid intake and breast cancer incidence, which has been confirmed by others, but no studies have considered simultaneously potential interactions of flavonoids with multiple genetic polymorphisms involved in biologically relevant pathways (oxidative stress, carcinogen metabolism, DNA repair, and one-carbon metabolism).

Methods

To estimate interaction effects between flavonoids and 13 polymorphisms in these four pathways on breast cancer risk, we used population-based data (n = 875 cases and 903 controls) and several statistical approaches, including conventional logistic regression and semi-Bayesian hierarchical modeling (incorporating prior information on the possible biologic functions of genes), which also

SUBMITTER: Khankari NK 

PROVIDER: S-EPMC3932534 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature