Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases.

ABSTRACT: Chemokines and their receptors are implicated in a wide range of human diseases, including acquired immune deficiency syndrome (AIDS). The entry of human immunodeficiency virus type 1 (HIV-1) into a cell is initiated by the interaction of the virus's surface envelope proteins with two cell surface components of the target cell, namely CD4 and a chemokine co-receptor, usually CXCR4 or CCR5. Typical anti-HIV-1 agents include protease and reverse transcriptase inhibitors, but the targets of these agents tend to show rapid mutation rates. As such, strategies based on HIV-1 co-receptors have appeal because they target invariant host determinants. Chemokines and their receptors are also of general interest since they play important roles in numerous physiological and pathological processes in ad

SUBMITTER: Choi WT 

PROVIDER: S-EPMC3932662 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature