Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21.

ABSTRACT:

Background and purpose

Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21, near CDKN2A and CDKN2B genes. Given that stroke is a common complication after myocardial infarction, we investigated if the same SNPs were associated with ischemic stroke in our population.

Methods

We recently initiated a whole genome analysis of ischemic stroke and published the first stage of a case control study using >400,000 SNPs from Illumina Infinium Human-1 and HumanHap300 assays. We focused on SNPs recently associated with heart disease by Helgadottir and colleagues and SNPs from the same haplotype block.

Results

In analyses both unadjusted and adjusted for stroke risk factors, signi

SUBMITTER: Matarin M 

PROVIDER: S-EPMC3932672 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature