Integrative annotation of 21,037 human genes validated by full-length cDNA clones.

ABSTRACT: The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of h

SUBMITTER: Imanishi T 

PROVIDER: S-EPMC393292 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature