Ontology highlight
ABSTRACT:
SUBMITTER: Faubert B
PROVIDER: S-EPMC3932920 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Faubert Brandon B Vincent Emma E EE Griss Takla T Samborska Bozena B Izreig Said S Svensson Robert U RU Mamer Orval A OA Avizonis Daina D Shackelford David B DB Shaw Reuben J RJ Jones Russell G RG
Proceedings of the National Academy of Sciences of the United States of America 20140203 7
One of the major metabolic changes associated with cellular transformation is enhanced nutrient utilization, which supports tumor progression by fueling both energy production and providing biosynthetic intermediates for growth. The liver kinase B1 (LKB1) is a serine/threonine kinase and tumor suppressor that couples bioenergetics to cell-growth control through regulation of mammalian target of rapamycin (mTOR) activity; however, the influence of LKB1 on tumor metabolism is not well defined. Her ...[more]