A statin-dependent QTL for GATM expression is associated with statin-induced myopathy.

ABSTRACT: Statins are prescribed widely to lower plasma low-density lipoprotein (LDL) concentrations and cardiovascular disease risk and have been shown to have beneficial effects in a broad range of patients. However, statins are associated with an increased risk, albeit small, of clinical myopathy and type 2 diabetes. Despite evidence for substantial genetic influence on LDL concentrations, pharmacogenomic trials have failed to identify genetic variations with large effects on either statin efficacy or toxicity, and have produced little information regarding mechanisms that modulate statin response. Here we identify a downstream target of statin treatment by screening for the effects of in vitro statin exposure on genetic associations with gene expression levels in lymphoblastoid cell lines derive

SUBMITTER: Mangravite LM 

PROVIDER: S-EPMC3933266 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature