Pulmonary disease after treatment for Wilms tumor: a report from the national wilms tumor long-term follow-up study.

ABSTRACT:

Purpose

This study was undertaken to evaluate the incidence of pulmonary disease among patients treated with radiation therapy (RT) for pulmonary metastases (PM) from Wilms tumor (WT).

Patients and methods

We reviewed records of 6,449 patients treated on National Wilms Tumor Studies-1, -2, -3, and -4 whose flow sheets or annual status reports documented one of several pulmonary conditions. Cases were fully evaluable if pulmonary function test (PFT) results were available, pulmonary fibrosis was identified on a chest radiograph or was listed as the primary or a contributing factor to death. Partially evaluable cases were those for whom PFT results could not be obtained. We evaluated the relationship between RT factors and the occurrence of pulmonary disease using hazard ratio

SUBMITTER: Green DM 

PROVIDER: S-EPMC3933277 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature