Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine.

ABSTRACT: Pharmacogenetics is being used to develop personalized therapies specific to subjects from different ethnic or racial groups. To date, pharmacogenetic studies have been primarily performed in trial cohorts consisting of non-Hispanic white subjects of European descent. A "bottleneck" or collapse of genetic diversity associated with the first human colonization of Europe during the Upper Paleolithic period, followed by the recent mixing of African, European, and Native American ancestries, has resulted in different ethnic groups with varying degrees of genetic diversity. Differences in genetic ancestry might introduce genetic variation, which has the potential to alter the therapeutic efficacy of commonly used asthma therapies, such as β2-adrenergic receptor agonists (β-agonists). Pharmacoge

SUBMITTER: Ortega VE 

PROVIDER: S-EPMC3933289 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature