T cell receptor signaling can directly enhance the avidity of CD28 ligand binding.

ABSTRACT: T cell activation takes place in the context of a spatial and kinetic reorganization of cell surface proteins and signaling molecules at the contact site with an antigen presenting cell, termed the immunological synapse. Coordination of the activation, recruitment, and signaling from T cell receptor (TCR) in conjunction with adhesion and costimulatory receptors regulates both the initiation and duration of signaling that is required for T cell activation. The costimulatory receptor, CD28, is an essential signaling molecule that determines the quality and quantity of T cell immune responses. Although the functional consequences of CD28 engagement are well described, the molecular mechanisms that regulate CD28 function are largely unknown. Using a micropipet adhesion frequency assay, we show

SUBMITTER: Sanchez-Lockhart M 

PROVIDER: S-EPMC3933428 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature