The association of arylendosulfatase 1 (SULF1) gene polymorphism with recurrent miscarriage.

ABSTRACT:

Purpose

One of the most common problems in reproductive medicine is recurrent miscarriage (RM). There is increasing evidence showing genetic susceptibility of women is an important risk factor in the occurrence of RM. In recent years, there is a growing interest in sulfate and its role in fetal development. A novel mechanism of SULF1 has been demonstrated for modifying the activities of some growth factors and signalling molecules that have major roles during embryogenesis. The aim of present study was to evaluate the association of SULF1 gene polymorphism (rs6990375 G > A) in Iranian patients with RM.

Methods

We established a case-control study of 200 Iranian women: 100 patients with the history of two or more RM as cases and 100 healthy women with at least two cases of suc

SUBMITTER: Zahraei M 

PROVIDER: S-EPMC3933597 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature