Variants in DPF3 and DSCAML1 are associated with sperm morphology.

ABSTRACT:

Purpose

Abnormalities in semen parameters are often associated with reduced fertility in males, and may, in part, be attributed to genetic variation. Aim of this study is to determine if genetic variants that were previously shown to be predictors of family size and birth rate in healthy men are also associated with sperm morphology in men recruited from an infertility laboratory.

Methods

Genetic associations with sperm morphology phenotypes in 126 ethnically diverse men from Chicago at 41 independent loci, previously shown to be predictors of family size and birth rate in healthy men, were tested.

Results

Two intronic SNPs, rs680730 (in DSCAML1) and rs10129954 (in DPF3), were associated with the percent of normal sperm morphology in Chicago men (P = 0.017 and 0.023,

SUBMITTER: Kosova G 

PROVIDER: S-EPMC3933604 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature