The organisational structure of protein networks: revisiting the centrality-lethality hypothesis.

ABSTRACT: Protein networks, describing physical interactions as well as functional associations between proteins, have been unravelled for many organisms in the recent past. Databases such as the STRING provide excellent resources for the analysis of such networks. In this contribution, we revisit the organisation of protein networks, particularly the centrality-lethality hypothesis, which hypothesises that nodes with higher centrality in a network are more likely to produce lethal phenotypes on removal, compared to nodes with lower centrality. We consider the protein networks of a diverse set of 20 organisms, with essentiality information available in the Database of Essential Genes and assess the relationship between centrality measures and lethality. For each of these organisms, we obtained netwo

SUBMITTER: Raman K 

PROVIDER: S-EPMC3933631 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature