Lipoprotein receptor-related protein-6 protects the brain from ischemic injury.

ABSTRACT:

Background and purpose

Loss-of-function mutations of the lipoprotein receptor-related protein-6 (LRP6), a coreceptor in the Wingless-related integration site-β-catenin prosurvival pathway, have been implicated in myocardial ischemia and neurodegeneration. However, it remains to be established whether LRP6 is also involved in ischemic brain injury. We used LRP6+/- mice to examine the role of this receptor in the mechanisms of focal cerebral ischemia.

Methods

Focal cerebral ischemia was induced by transient occlusion of the middle cerebral artery. Motor deficits and infarct volume were assessed 3 days later. Glycogen-synthase-kinase-3β (GSK-3β) phosphorylation was examined by Western blotting with phosphospecific antibodies, and the mitochondrial membrane potential changes ind

SUBMITTER: Abe T 

PROVIDER: S-EPMC3933931 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature