Cytoplasmic irradiation results in mitochondrial dysfunction and DRP1-dependent mitochondrial fission.

ABSTRACT: Direct DNA damage is often considered the primary cause of cancer in patients exposed to ionizing radiation or environmental carcinogens. Although mitochondria are known to play an important role in radiation-induced cellular response, the mechanisms by which cytoplasmic stimuli modulate mitochondrial dynamics and functions are largely unknown. In the present study, we examined changes in mitochondrial dynamics and functions triggered by α particle damage to the mitochondria in human small airway epithelial cells, using a precision microbeam irradiator with a beam width of 1 μm. Targeted cytoplasmic irradiation using this device resulted in mitochondrial fragmentation and a reduction of cytochrome c oxidase and succinate dehydrogenase activity, when compared with nonirradiated controls, su

SUBMITTER: Zhang B 

PROVIDER: S-EPMC3934017 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature