Advancing the biobehavioral research of fatigue with genetics and genomics.

ABSTRACT:

Purpose

To examine phenotypic considerations in the study of fatigue and to explore significant issues affecting the extension of biobehavioral research of fatigue by the inclusion of genetic and genomic markers. THEORETICAL ORGANIZATION: Fatigue is a condition that has an adverse effect on quality of life that has been a focus of nursing inquiry. Yet, the study of fatigue has been stymied by the lack of phenotypic clarity. To expand the biobehavioral inquiry of fatigue, phenotypic clarity is needed. In addition, examining genomic factors associated with fatigue may help to elucidate the pathophysiology of fatigue and, in the future, lead to targeted interventions that address the molecular basis of fatigue.

Conclusions

Given that nursing has been at the forefront of the stu

SUBMITTER: Lyon DE 

PROVIDER: S-EPMC3934428 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature