Targeting cell death signaling in colorectal cancer: current strategies and future perspectives.

ABSTRACT: The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in colorectal cancer. Nearly any non-invasive cancer treatment finally aims to induce cell death. However, apoptosis resistance is the major cause for insufficient therapeutic success and disease relapse in gastrointestinal oncology. Various compounds have been developed and evaluated with the aim to meet with this obstacle by triggering cell death in cancer cells. The aim of this review is to illustrate current approaches and future directions in targeting cell death signaling in colorectal cancer. The complex signaling network of apoptosis will be demonstrated and the "druggability" of targets will be identified. In det

SUBMITTER: Koehler BC 

PROVIDER: S-EPMC3934462 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature