Association between the COMTVal158Met Genotype and Alzheimer's Disease in the Han Chinese Population.

ABSTRACT:

Background

Alzheimer's disease (AD) is the leading cause of dementia worldwide and is associated with individual, familial and social burdens. Catechol-O-methyltransferase (COMT) may have a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Although the COMT rs4680 gene polymorphism has been investigated as a susceptibility factor for AD, the results are inconsistent. The aim of this study was to examine the influence of the COMT rs4680 gene polymorphism as a risk factor for AD in the Han Chinese population and its synergistic effect with the apolipoprotein E (APOE)gene.

Methods

A total of 137 AD patients and 194 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish

SUBMITTER: Ji Y 

PROVIDER: S-EPMC3934601 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature