Sex differences in the effect of puberty on hippocampal morphology.

ABSTRACT:

Objective

Puberty is the defining process of adolescence, and is accompanied by divergent trajectories of behavior and cognition for males and females. Here we examine whether sex differences exist in the effect of puberty on the morphology of the hippocampus and amygdala.

Method

T1-weighted structural neuroimaging was performed in a sample of 524 pre- or postpubertal individuals ages 10 to 22 years. Hippocampal and amygdala volume and shape were quantified using the Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library (FSL) FIRST procedure and scaled by intracranial volume. The effects on regional volume of age, sex, puberty, and their interactions were examined using linear regression. Postpubertal sex differences were examined using a vertex analysi

SUBMITTER: Satterthwaite TD 

PROVIDER: S-EPMC3935178 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature