Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study.

ABSTRACT:

Background

Many studies have shown that exposures to air pollution are associated with cardiovascular events, although the mechanism remains to be clarified. To identify whether exposures to ambient particles act on autonomic function via the lipid/endothelial metabolism pathway, whether effects of particulate matter <2.5 mum in aerodynamic diameter (PM(2.5)) on heart rate variability (HRV) were modified by gene polymorphisms related to those pathways were evaluated.

Methods

HRV and gene data from the Normative Aging Study and PM(2.5) from a monitor located a kilometre from the examination site were used. A mixed model was fitted to investigate the associations between PM(2.5) and repeated measurements of HRV by gene polymorphisms of apolipoprotein E (APOE), lipoprotein lipa

SUBMITTER: Ren C 

PROVIDER: S-EPMC3935361 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature