The ecological basis of morphogenesis: branching patterns in swarming colonies of bacteria.

ABSTRACT: Understanding how large-scale shapes in tissues, organs and bacterial colonies emerge from local interactions among cells and how these shapes remain stable over time are two fundamental problems in biology. Here we investigate branching morphogenesis in an experimental model system, swarming colonies of the bacterium Pseudomonas aeruginosa. We combine experiments and computer simulation to show that a simple ecological model of population dispersal can describe the emergence of branching patterns. In our system, morphogenesis depends on two counteracting processes that act on different length-scales: (1) colony expansion, which increases the likelihood of colonizing a patch at a close distance and (2) colony repulsion, which decreases the colonization likelihood over a longer dista

SUBMITTER: Deng P 

PROVIDER: S-EPMC3935381 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature