Correlate of immune protection against HSV-1 genital disease in vaccinated women.

ABSTRACT:

Background

Previously we conducted a double-blind controlled, randomized efficacy field trial of gD-2 HSV vaccine adjuvanted with ASO4 in 8323 women. Subjects had been previously selected to be seronegative for HSV-1 and HSV-2. We found that vaccine was 82% protective against HSV-1 genital disease, but offered no significant protection against HSV-2 genital disease.

Methods

To better understand the results of the efficacy study, post-vaccination anti-gD-2 antibody concentrations from all HSV infected subjects and matched uninfected controls were measured. Three models were used to determine whether thes responses correlated with protection against HSV infection or disease. Similarly, cellular immune responses from a subset of subjects and matched controls were evaluated for

SUBMITTER: Belshe RB 

PROVIDER: S-EPMC3935479 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature