Structure-activity relationships for perfluoroalkane-induced in vitro interference with rat liver mitochondrial respiration.

ABSTRACT: Perfluorinated alkyl acids (PFAAs) represent a broad class of commercial products designed primarily for the coatings industry. However, detection of residues globally in a variety of species led to the discontinuation of production in the U.S. Although PFAAs cause activation of the PPARα and CAR nuclear receptors, interference with mitochondrial bioenergetics has been implicated as an alternative mechanism of cytotoxicity. Although the mechanisms by which the eight carbon chain PFAAs interfere with mitochondrial bioenergetics are fairly well described, the activities of the more highly substituted or shorter chain PFAAs are far less well characterized. The current investigation was designed to explore structure-activity relationships by which PFAAs interfere with mitochondrial respiration

SUBMITTER: Wallace KB 

PROVIDER: S-EPMC3935505 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature