Epigenetic modulation of signal transduction pathways in HPV-associated HNSCC.

ABSTRACT:

Objective

Human papilloma virus (HPV) positive and HPV negative head and neck squamous cell cancer (HNSCC) are biologically distinct with a prognostic advantage for HPV positive patients compared to HPV negative cases. DNA promoter methylation is central to human diseases such as cancer, including HNSCC, with reported genome-wide hypomethylaton and promoter hypermethylation in HPV positive HNSCC tumors. The goal of this study was to identify differentially methylated genes in HPV positive versus HPV negative primary HNSCC genomes with clues to signaling networks.

Study design

Laboratory-based study.

Setting

Primary care academic health care system.

Subjects and methods

DNA from 4 HPV positive and 4 HPV negative freshly frozen primary HNSCC were subject to compr

SUBMITTER: Worsham MJ 

PROVIDER: S-EPMC3935612 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature