Ontology highlight
ABSTRACT:
SUBMITTER: Wang IX
PROVIDER: S-EPMC3935819 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Cell reports 20131031 3
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells. Then, we followed up the findings experimentally with siRNA knockdown and RNA and protein immunoprecipitations. The results uncovered over 60,000 A-to-G editing sites and several thousand genes whose expression levels are influenced by ADARs. Of these ADAR ...[more]