No association of four candidate genetic variants in MnSOD and SYNIII with Parkinson's disease in two Chinese populations.

ABSTRACT:

Background

The manganese superoxide dismutase (MnSOD) gene, which encodes a chief reactive oxygen species (ROS) scavenging enzyme, has been reported to be associated with the risk of developing sporadic Parkinson's disease (PD) in some Asian races and the synapsin III (SYN3) gene with some neuropsychiatric diseases.

Objective

To explore the associations between the MnSOD and SYN III variations and PD in two Chinese populations from mainland China and Singapore.

Methods

We recruited 2342 subjects including 1200 sporadic PD patients and 1142 healthy controls from two independent Asian countries. Using a case-control methodology, we genotyped the single nucleotide polymorphisms (SNP) in MnSOD (rs4880) and SYN III (rs3788470, rs3827336, rs5998557) to explore the associati

SUBMITTER: Yu WJ 

PROVIDER: S-EPMC3935830 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature