MicroRNA gene polymorphisms and environmental factors increase patient susceptibility to hepatocellular carcinoma.

ABSTRACT:

Background

Micro RNAs (miRNAs) are small RNA fragments that naturally exist in the human body. Through various physiological mechanisms, miRNAs can generate different functions for regulating RNA protein levels and balancing abnormalities. Abnormal miRNA expression has been reported to be highly related to several diseases and cancers. Single-nucleotide polymorphisms (SNPs) in miRNAs have been reported to increase patient susceptibility and affect patient prognosis and survival. We adopted a case-control research design to verify the relationship between miRNAs and hepatocellular carcinoma.

Methodology/principal findings

A total of 525 subjects, including 377 controls and 188 hepatocellular carcinoma patients, were selected. Polymerase chain reaction-restriction fragment len

SUBMITTER: Chu YH 

PROVIDER: S-EPMC3935960 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature