Marked and persistent eosinophilia in the absence of clinical manifestations.

ABSTRACT:

Background

Although most patients with hypereosinophilic syndromes (HES) present with clinical signs and symptoms attributable to eosinophilic tissue infiltration, some untreated patients remain asymptomatic or have signs and symptoms, such as allergic rhinitis, for which the relationship to peripheral eosinophilia is unclear (hypereosinophilia of unknown significance [HEUS]).

Objective

To identify and characterize subjects with HEUS of 5 years duration or more as compared to untreated patients with symptomatic HES and healthy normal volunteers.

Methods

All subjects with eosinophilia underwent yearly evaluation, including a standardized clinical evaluation, whole blood flow cytometry to assess lymphocyte subsets and eosinophil activation, and serum collection. Periphe

SUBMITTER: Chen YY 

PROVIDER: S-EPMC3935986 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature