COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus.

ABSTRACT:

Purpose

Collagen involvement in myopia development via scleral remodeling is well-known. Recently, COL1A1 and COL2A1 gene polymorphisms were reported to be associated with high-grade and common myopia, respectively. This study was conducted to investigate whether these collagen genes are associated and/or genetically linked with myopia in large Caucasian family datasets.

Methods

High-grade myopia was defined as

SUBMITTER: Metlapally R 

PROVIDER: S-EPMC3936411 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature