ChroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome.

ABSTRACT: Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question. chroGPS uses multidimensional scaling techniques to represent similarity between epigenetic factors, or between genetic elements on the basis of their epigenetic state, in 2D/3D reference maps. We emphasize biological interpretability, statistical robustness, integration of genetic and epigenetic data from heterogeneous sources, and computational feasibility. Although chroGPS is a general methodology to create reference maps and study the epigenetic state of any class of genetic element or genomic region, we focus on two specific kinds of maps: chroGPS(factors), which visualizes functional similarities between epigenetic factors, and

SUBMITTER: Font-Burgada J 

PROVIDER: S-EPMC3936722 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature