Genetic robustness and functional evolution of gene duplicates.

ABSTRACT: Gene duplications are a major source of evolutionary innovations. Understanding the functional divergence of duplicates and their role in genetic robustness is an important challenge in biology. Previously, analyses of genetic robustness were primarily focused on duplicates essentiality and epistasis in several laboratory conditions. In this study, we use several quantitative data sets to understand compensatory interactions between Saccharomyces cerevisiae duplicates that are likely to be relevant in natural biological populations. We find that, owing to their high functional load, close duplicates are unlikely to provide substantial backup in the context of large natural populations. Interestingly, as duplicates diverge from each other, their overall functional load is reduced. At interm

SUBMITTER: Plata G 

PROVIDER: S-EPMC3936732 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature