The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women.

ABSTRACT:

Background

Regular smoking is associated with a wide variety of syndromes with prominent inflammatory components such as cancer, obesity and type 2 diabetes. Heavy regular smoking is also associated with changes in the DNA methylation of peripheral mononuclear cells. However, in younger smokers, inflammatory epigenetic findings are largely absent which suggests the inflammatory response(s) to smoking may be dose dependent. To help understand whether peripheral mononuclear cells have a role in mediating these responses in older smokers with higher cumulative smoke exposure, we examined genome-wide DNA methylation in a group of well characterized adult African American subjects informative for smoking, as well as serum C-reactive protein (CRP) and interleukin-6 receptor (IL6R) levels

SUBMITTER: Dogan MV 

PROVIDER: S-EPMC3936875 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature