Hyperglycemia and arterial stiffness: the Atherosclerosis Risk in the Communities study.

ABSTRACT:

Objectives

Hyperglycemia has been associated with an increased risk of cardiovascular morbidity and mortality. Although numerous studies have demonstrated that hyperglycemia is associated with the atherosis component of atherosclerosis, limited studies have addressed the independent role of hyperglycemia in the pathophysiology of sclerotic vascular disease. We hypothesized that hyperglycemia, as assessed by hemoglobin A1c (HbA1c), would be independently associated two common indices of arterial stiffness (pressure-strain elastic modulus (Ep) and Young's elastic modulus (YEM)).

Methods

We examined the cross-sectional association between HbA1c and arterial stiffness using B-mode ultrasound examination of the carotid artery in 9050 participants from the community-based Atherosc

SUBMITTER: Rubin J 

PROVIDER: S-EPMC3936879 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature