Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128.

ABSTRACT: MicroRNAs, the non-coding single-stranded RNA of 19-25 nucleotides are emerging as robust players of gene regulation. Plethora of evidences support that the ability of microRNAs to regulate several genes of a pathway or even multiple cross talking pathways have significant impact on a complex regulatory network and ultimately the physiological processes and diseases. Brain being a complex organ with several cell types, expresses more distinct miRNAs than any other tissues. This review aims to discuss about the microRNAs in brain development, function and their dysfunction in brain tumors. We also provide a comprehensive summary of targets of brain specific and brain enriched miRNAs that contribute to the diversity and plasticity of the brain. In particular, we uncover recent findings on mi

SUBMITTER: Adlakha YK 

PROVIDER: S-EPMC3936914 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature